His Eminence Jaime Cardinal L. Sin, D.D., the former Archbishop of Manila is the founder of the Lorenzo Mission Institute in 1987 and the Lorenzo Ruiz Mission Society in 1997.
Msgr. John Su became the founding Rector of the Lorenzo Mission Institute. He served as rector in the years 1987 to 1993.
The first 5 Seminarians formed the first community of the Lorenzo Mission Institute in 1987.
Fr. Karl Steinmetz SJ, (center) became the first spiritual director of the Lorenzo Mission Institute. He served the seminarians in the years 1987- 1990.
In 1987, Bishop Teodoro C. Buhain, D.D. was the National Coordinator of the Filipino-Chinese Apostolate in the Philippines when the Lorenzo Mission Institute was founded.
In 1988, Archbishop Oscar V. Cruz, the former Archbishop of Lingayen-Dagupan drafted the Directory of the Lorenzo Ruiz Mission Society.
The seminary, Lorenzo Mission Institute, was completed in 1989.
In 1989, Bishop Crisostomo Yalung became the first Vice Rector and Dean of Seminarians of the Lorenzo Mission Institute. He journeyed with the seminary for 5 years.
In 1989, Bishop Luke Liu Hsien Tang of Hsin Chu, Taiwan made his first visit to the Lorenzo Mission Institute. It is having a foresight of studying and learning Chinese in the Diocese of Hsinchu and welcoming members of the society to work as missionaries in Hsinchu after seminary formation.
In 1990, Fr. Esteban U. Lo, LRMS became the first one to be ordained as deacon at the Lorenzo Mission Institute Chapel and priest of the Lorenzo Mission Institute to be ordained by His Eminence Jaime Cardinal Sin, D.D. in 1991 at Queen of Peace Parish, Bacolod City.
In 1990, Msgr. Charles Tschou became the first Oeconomus of the Lorenzo Mission Institute.
Pope St. John Paul II became the first pope to visit the Lorenzo Mission Institute in 1995 on the occasion of the 10th World Youth Day in Manila. The beginnings of the emergence of the seminary can be traced from the inspirations of the mission theology of John Paul II for Asia.
In 1997, as the Lorenzo Ruiz Mission Society was officially established, Msgr. Paul Lu, PME became the first Superior of the Society. He became also the second Rector of the Lorenzo Mission Institute
Bishop Peter Feng Xin Mao became the first alumnus bishop of the Lorenzo Mission Institute. He was ordained to the Episcopacy in 2004 and now Bishop of the Diocese of Jingxian.
In 2006, Bishop Paul Jaucian D.D., National Coordinator of the Filipino-Chinese Apostolate in the Philippines made his first visit to the Lorenzo Mission Institute on the occasion of the Filipino-Chinese Apostolate national consultation and aggiornamento.
In 2010, Joseph Cardinal Zen Ze Kiun, 6th Bishop of HongKong visited the Lorenzo Mission Institute for the first time. He gave a conference on the situation and current challenges of Catholic Church and mission in Hong Kong, Taiwan and in China.
In 2012, the Lorenzo Mission Institute celebrated its 25th year anniversary of its foundation. There were 38 seminarians during its silver anniversary.
On February 19, 2015, the Orientation Year Building was blessed by His Eminence Luis Antonio G. Cardinal Tagle, D.D.